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dc.contributor.authorChikhaoui, Abderrahime-
dc.description.abstractThe aim of this thesis is to evaluate and investigate some of turmeric biological activities using two different studies: The experimental assay focused on evaluating the antioxidant capacities of some curcuminoids by utilizing the scavenging properties of hydroxyl radical and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical; to obtain these curcuminoids, an extraction process was carried out, column chromatography was needed to separate each one of the analogues, then characterized by Fourier-transform infrared spectroscopy (FT-IR). The theoretical approach investigates same curcuminoids docked with The Transient Receptor Potential cation channel subfamily V member 1 or TRPV1 protein (PDB ID: 5IS0) to predict their putative interactions and review its inhibition capabilities towards the selected active site and compare the results to the ligand of reference (Capsazepine) After running a DFT calculations to minimize and optimize all the curcuminoids in scope.en_US
dc.subjectAntioxidant, Capsazepine, DFT, Docking, DPPH, extraction, FT-IR, separation, TRPV1, Turmericen_US
dc.titleExperimental, Spectral Characterization and Docking Studies of some bioactive agentsen_US
Appears in Collections:Faculté des Sciences Exactes et des Sciences de la Nature et de la Vie (FSESNV)

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